Could Aging Human Skin Use a Connective Tissue Growth Factor Boost to Increase Collagen Content?

The roles of connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-β, and type I procollagen expression and content. CTGF knockdown and TGF-β blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-β/Smad signaling–dependent mechanism without involving Smad2/3.

Link: 10.1038/jid.2009.331

Share this publication

More publications

Computational modeling of peritoneal dialysis: An overview

Authors: Sangita Swapnasrita, Joost C. de Vries, Carl M. Öberg, Aurélie M.F. Carlier, Karin G.F. Gerritsen
Journal: American Journal of Kidney Diseases
Year: 2025

Read more

The Future of Technology-Based Kidney Replacement Therapies: An Update on Portable, Wearable and Implantable Artificial Kidneys

Authors: Fokko P. Wieringa, Swathi Suran, Henning Søndergaard, Stephen R. Ash, Cian Cummins, Ashesh Ray Chaudhury, Tugrul Irmak, Karin G.F. Gerritsen, Jeroen C. Vollenbroek
Journal: American Journal of Kidney Diseases
Year: 2025

Read more

Transportable, portable, wearable and (partially) implantable haemodialysis systems: comparison of technologies and readiness levels

Authors: Fokko P. Wieringa, Dian P. Bolhuis, Henning Søndergaard, Stephen R. Ash, Cian Cummins, Karin G.F. Gerritsen, Jeroen C. Vollenbroek, Tugrul Irmak
Journal: Clinical Kidney Journal
Year: 2024

Read more